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Atlas Of Diagnostic Pathology Of The Cervix A C...

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Atlas Of Diagnostic Pathology Of The Cervix A C...

Fractures of the C1 vertebrae (atlas) are commonly the result of falls and other trauma, which cause hyperextension, or axial compression of the cervical spine. Although historically thought as a benign injury with lower neurological risks, current data suggests that this may not hold true for geriatric patients (aged 65 y and older) who may be predisposed to these fractures even after lower-energy trauma such as ground-level falls. Advancements in orthopedic trauma care has increased our diagnostic abilities to identify and manage patients with C1 fractures and other upper cervical spine trauma. However, there are no universal treatment guidelines based on level I trials. Current treatment ranges from nonoperative to operative management depending on fracture-pattern and integrity of the surrounding ligaments. Furthermore, in the elderly patients these fractures present a unique dilemma due to preexisting comorbidities and contraindications to various treatment modalities. C1 fractures warrant greater recognition to provide optimal treatment to patients and minimize the risk for developing complications. The goal of this review is to highlight the most updated treatment guidelines and to discuss the complications of both operative and nonoperative management of C1 fractures especially among the elderly patient population.

Manual scoring of PDL-1 IHC slides by pathologists may be a potential source of error. The increasing adoption of digital pathology and artificial intelligence in daily workflow of the laboratory provides an opportunity to leverage these tools towards improving the clinical value of PD-L1 IHC assays. Several recent studies have demonstrated that automated digital image analysis provides accuracy and consistency comparable to manual scoring. As such, image analysis scoring could serve as a crucial aid for pathologists in PD-L1 diagnostic testing [27,28,29].

Separate scraping of material from the endocervix and walls of uterine corpus in a set in order to determine which site may be the source of the malignancy. This is the preferred diagnostic procedure for endometrial cancer.

This latest version of the Atlas of Non-melanocytic Tumors of the Skin is rich in illustrations, aimed to highlight important diagnostic aspects of individual cutaneous epithelial, mesenchymal, hematopoietic and lymphoid tumors, and to delineate their morphologic spectrum. The images are supplemented by concise text to emphasize the salient clinical and histologic features, differential diagnosis, and the use of immunohistochemistry and other ancillary tests. The goal is to provide a practical diagnostic guide that will serve as a useful resource for dermatopathology and surgical pathology practice.

The primary goal of this fascicle is to be a practical reference for pathologists who review liver biopsies, a most challenging area of diagnostic surgical pathology. It is focused on diagnostic histopathology, discussing and lavishly illustrating disease patterns with an emphasis on differential diagnosis. The key aspects of clinical features, laboratory findings, and pathophysiology are woven into this book. The application and interpretation of special stains and immunohistochemistry are integrated into discussions of each disease pattern. 781b155fdc


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